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The principal cytochrome P450 isoenzyme concerned seems to be CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Roughly 85% of the oral dose appears during the urine inside of 24 hrs of administration, most given that the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information an